منابع مشابه
Self-renewal of embryonic stem cells by a small molecule.
A cell-based screen of chemical libraries was carried out to identify small molecules that control the self-renewal of ES cells. A previously uncharacterized heterocycle, SC1, was discovered that allows one to propagate murine ES cells in an undifferentiated, pluripotent state under chemically defined conditions in the absence of feeder cells, serum, and leukemia inhibitory factor. Long-term SC...
متن کاملSelf-Renewal of Stem Cells
Asymmetric division is one of the most fundamental characteristics of adult stem cells , which ensures one daughter cell maintains stem cell status and the other daughter cell becomes committed to differentiation. New data emerged recently that allow us to conclude that asymmetric division has another important aspect: it enables self-maintenance of stem cells.
متن کاملCancer stem cells and self-renewal.
The cancer stem cell (CSC) or cancer-initiating cancer (C-IC) model has garnered considerable attention over the past several years since Dick and colleagues published a seminal report showing that a hierarchy exists among leukemic cells. In more recent years, a similar hierarchical organization, at the apex of which exists the CSC, has been identified in a variety of solid tumors. Human CSCs a...
متن کاملHighlight: self-renewal signaling in stem cells.
A number of ground-breaking studies recently identified sets of nuclear factors that together have the unique ability to ‘reset’ an adult differentiated cell type and to ‘erase’ all previous fate decisions and the transcriptional programs that determine phenotype and function of a differentiated cell (Takahashi et al., 2007; Wernig et al., 2007; Yu et al., 2007). As a result, ‘reprogrammed’ cel...
متن کاملSmall RNAs: Keeping Stem Cells in Line
Stem cells and RNA silencing have emerged as areas of intense interest for both basic and clinical research. Recently these fields have converged with reports implicating small regulatory RNAs in the maintenance and pluripotency of stem cells.
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ژورنال
عنوان ژورنال: Cell Research
سال: 2008
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2008.99